Clooney: 'Hollywood success is random'

George Clooney on cover of Vanity Fair

George Clooney attributes his phenomenal success as an actor to "random" blind luck.

The 46-year-old is aware he owes his Hollywood superstar status to landing the lead on E.R. as a doctor.

He says, "Think about how random things are. For me, it required a Thursday night time slot for a medical show.

"There had only been two shows in 16 years - L.A. Law and Hill Street Blues - and it opened up. We had a show, and immediately everything changed.

"And you go, 'That has nothing to do with me.' That has to do with pure luck all the way around."