Rafa Nadal and Roger Federer, numbers two and three in the world, suffered surprise defeats to inspired opponents in an entertaining quarter-finals day at the Cincinnati Open on Friday.
Champion Kim Clijsters has pulled out of the US Open due to a stomach muscle injury, the Belgian said in a statement on Friday.
Australian Samantha Stosur has bucked the trend of on-court coaching and the world number 10 believes she benefits from managing matches on her own.
Grand slam title holders Li Na and Petra Kvitova were knocked out of the Cincinnati Open on Thursday while Russia's Maria Sharapova and Vera Zvonareva moved into the quarter-finals.
France's Jo-Wilfried Tsonga suffered a surprise defeat to qualifier Alex Bogomolov while Spain's Rafa Nadal and world number one Novak Djokovic passed their second-round tests at the Cincinnati Open.
World number one Caroline Wozniacki suffered a shock second-round loss to 19-year-old American Christina McHale at the Cincinnati Open on Wednesday.
An angry and frustrated Andy Roddick lost his cool as he crashed out of the Cincinnati Open in the first round on Monday, suffering a three-set loss to 47th-ranked German Philipp Kohlschreiber.
Novak Djokovic has been out of this world but the world number one says he is still just flesh and blood.
World number one Novak Djokovic advanced to the final of the Montreal Masters when Frenchman Jo Wilfried Tsonga retired trailing 6-4 3-0 on Saturday.
Mardy Fish swept past Serb Janko Tipsarevic 6-3 6-4 at the Montreal Masters on Saturday to reach his third consecutive final and lift the gloom hanging over American tennis.
Jo-Wilfried Tsonga hit Roger Federer with an unpleasant Wimbledon flashback on Thursday, brushing aside the Swiss maestro 7-6 4-6 6-1 to book his place in an unlikely quarter-final line-up at the Montreal Masters.
French Open champion Li Na said she had played like a "junior" during a surprise third-round loss at the Toronto Cup that left her to join three other rusty top seeds eliminated on Thursday.