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Chinese scientists find possible cell therapy for multiple myeloma

Xinhua | Updated: 2017-06-06 10:59

Chinese scientists presented a possible cell therapy for multiple myeloma at the 2017 annual meeting of the American Society of Clinical Oncology (ASCO) held here in Chicago on Monday.

Data collected by Chinese scientists in an early clinical trial show that the therapy, called chimeric antigen receptor (CAR) T-cell immunotherapy, could be a safe and effective way to treat relapsed or refractory multiple myeloma.

The ongoing early-phase clinical trial of the therapy conducted at the Second Affiliated Hospital of Xi'an Jiaotong University in Xi'an, China, shows that 33 out of 35 patients who have their multiple myeloma relapsed on previous treatments reported clinical remission within two months after receiving experimental CAR T-cell products targeting B-cell maturation protein (BCMA).

The first 35 patients enrolled in the ongoing clinical trial have received three split doses of 20 percent, 30 percent and 50 percent, respectively, over a week, and the first signs of treatment efficacy appeared as early as 10 days after the initial injection.

During clinical trial, Chinese researchers have followed 19 patients for more than four months, a consensus criteria time for full efficacy assessment set by the International Myeloma Working Group (IMWG), and found that 14 reached stringent complete response (sCR) criteria, which means there is no detectable plasma cells in the patient's bone marrow or myeloma proteins in the serum or urine; one reached partial response; and four achieved very good partial remission criteria (VgPR) in efficacy.

There has not been a single case of relapse among the 14 patients who reached sCR criteria, and of the five out of the 14 patients that have been followed for over a year, all remain at sCR status.

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