An epidemic in 2001 devastated Britain's livestock industry, as the government slaughtered 6 million sheep, cows and pigs. Last year, in a less serious outbreak, Britain's health and safety agency concluded the virus probably escaped from a site shared by a government research center and a vaccine maker.
If even a single cow signals an outbreak in the US, emergency plans permit the government to shut down all exports and movement of livestock. Herds would be quarantined, and a controlled slaughter could be started to stop the disease from spreading.
Infected animals weaken and lose weight. Milk cows don't produce milk. They remain highly infectious, even if they survive the virus.
The Homeland Security Department is convinced it can safely operate the lab on the mainland, saying containment procedures at high-security labs have improved. The livestock industry is divided. Some experts, including the former director at the aging Plum Island Animal Disease Center, say research ought to be kept away from cattle populations - and, ideally, placed where the public already has accepted dangerous research.
The former director, Dr. Roger Breeze, suggested the facility could be safely located at the Atlanta campus of the Centers for Disease Control and Prevention, or at Fort Detrick in Frederick, Md., home of The United States Army Medical Research Institute for infectious diseases.
Another possibility, Breeze said, is on Long Island, where there is no commercial livestock industry. That would allow retention of most of the current Plum Island employees.
Asked about the administration's finalist sites located near livestock, Breeze said: "It seems a little odd. It goes against the ... safety program of the last 50 years."
The former head of the US Agriculture Department's Agricultural Research Service said Americans are not prepared for a foot-and-mouth outbreak that has been avoided on the mainland since 1929.
"The horrific prospect of exterminating potentially millions of animals is not something this country's ready for," said Dr. Floyd Horn.
The Agriculture Department ran the Plum Island lab until 2003. It was turned over to the Homeland Security Department because preventing an outbreak is now part of the nation's biological defense program.
Plum Island researchers work on detection of the disease, strategies to control epidemics including vaccines and drugs, tests of imported animals to ensure they are free of the virus and training of professionals.
The new facility will add research on diseases that can be transferred from animals to humans. The Plum Island facility is not secure enough to handle that higher-level research.
Leaders of the House Energy and Commerce Committee also are worried about the lab's likely move to the mainland. The chairman, Rep. John Dingell, D-Mich., and the head of the investigations subcommittee, Rep. Bart Stupak, D-Mich., are threatening to subpoena records they say Homeland Security is withholding from Congress. Those records include reports about "Crimson Sky," an internal review about a publicized 1978 accidental release of foot-and-mouth disease on Plum Island and reports about any previously undisclosed virus releases on the island during the past half century.
The lawmakers set a deadline of Friday for the administration to turn over reports they requested. Otherwise, they warned in a letter to Homeland Security Secretary Michael Chertoff, they will arrange a vote next week to issue a congressional subpoena.