Cloned monkeys shed light on circadian disorders

The research will also help reduce the quantity of macaques used in biological research around the world, Poo said.

"Without the interference of diverse genetic backgrounds, a much smaller number of cloned monkeys carrying disease phenotypes may be sufficient for preclinical tests of the efficacy of therapeutics," he said.

The donor monkey, despite the presence of the BMAL1 gene, had exhibited circadian disorders－which in humans can lead to other diseases, including sleep disorders, diabetic mellitus, cancer and neurodegenerative disorders such as Alzheimer's disease.

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