Hopes of a vaccine for cancer received a boost this week following trials of
a new therapy that successfully blocked tumour growth in animals.
The experimental vaccine protected animals from cancer for up to five months,
and stopped tumours growing bigger in those that already had the disease.
Researchers at the Karolinska Institute cancer centre in Stockholm are now
adapting the vaccine for use in humans, and believe it could help to stop a
variety of tumours recurring in patients who have already been treated with
surgery, chemotherapy or radiotherapy.
The vaccine was developed following the discovery in 1990 of angiostatin, a
drug that stops tumours growing new blood vessels, in effect starving them of
oxygen and nutrients.
Some experts predicted angiostatin would become a magic bullet for cancer,
but trials found it did not last long enough in the body to be effective in a
vaccine.
For the latest trial, Lars Holmgren and his team developed a DNA-based cancer
vaccine that fools the body into producing antibodies that mimic angiostatin.
Because the antibodies last longer in the bloodstream, they are more effective
than angiostatin.
In a trial, researchers transplanted breast tumours into mice before giving
them two injections of the vaccine, two weeks apart. The first injection primed
the immune system and the second acted as a booster. The trial showed the
vaccine triggered a release of antibodies that suppressed tumour growth for up
to 150 days. The mice showed no side effects.
In a second trial, genetically engineered mice bred to develop breast cancer
within 28 days were given a modified version of the DNA vaccine that also
blocked a gene linked to cancer.
"Normally all these mice develop cancer within a month, but in the trial 80
per cent remained cancer-free and lived for up to one and a half years," said
Holmgren, whose study was published in the Proceedings of the National Academy
of Sciences on Monday.
The researchers believe the vaccine was successful because it works
differently from previous DNA vaccines. Instead of targeting cancerous cells
that are constantly mutating, the vaccine acts on healthy cells that the tumour
recruits to build up its blood supply.
The researchers have teamed up with a Swedish company to manufacture
antibodies that could be used in a human cancer vaccine. If the vaccine is
effective in human trials, it could potentially help give protection against a
range of cancer varieties.
A cancer vaccine could be used to prevent cancers returning in patients who
have already been operated on, or received chemotherapy or
radiotherapy.