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George Clooney to appear in final episodes of 'ER' March 12
(Agencies)
Updated: 2009-02-27 18:54

George Clooney is set to appear on one of the final episodes of "ER" will air on NBC that evening.

Clooney is set to return as Dr. Doug Ross on the long-running medical series that helped make him an A-list star. The episode marks a reunion for Dr. Ross and his longtime love, nurse Carol Hathaway, played by fellow erstwhile "ER" actor Juliana Margulies. Clooney and Margulies left the show in 1999 and 2000, respectively, , according a report from nydailynews.

The episode will also feature Susan Sarandon as a grief-stricken grandmother.

"If you're a fan of 'ER,' you won't want to miss this one," executive producer John Wells told People magazine.

"ER" made its debut in 1995. The two-hour final episode will air April 2 on NBC.