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The actor was born John Arthur Carradine on December 8, 1936, in Los Angeles and was educated at San Francisco State University, where he studied music theory and composition.
While writing music for the drama department's annual revues, he discovered his own passion for the stage, joining a Shakespearean repertory company.
After working on Broadway in "The Deputy" and "The Royal Hunt of the Sun" opposite Christopher Plummer, Carradine earned a spot on Hollywood's map in the 1960s in TV westerns such as "Wagon Train" and "The Virginian" as well as his starring role in a TV version of the hit western movie "Shane."
But it was his role in "Kung Fu" that earned the actor his greatest fame. The series aired on U.S. television starting in 1972 and immediately won a large fan base for Carradine as Caine, a half-Asian martial arts expert and student of life.
The show spawned a movie and numerous other offshoots. Overall, Carradine's credits include more than 200 roles in movies, TV, video and DVD spanning nearly five decades.
His role as Caine earned him a nomination for an Emmy, U.S. TV's highest honor, and his turn as the villainous Bill in "Kill Bill: Vol. 2" led to his fourth Golden Globe nomination. He also won critical acclaim for portraying folk singer Woody Guthrie in the Oscar-nominated 1976 film "Bound for Glory."
Carradine was married five times and had two daughters from previous marriages. His latest wife was Annie Bierman, whom he married in 2004. His brothers include actor Keith Carradine.