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Updated: 2003-09-29 01:00

Man's best friend, genetically more like him than a mouse
狗——人类最亲密的朋友

Dogs are genetically closer to man than mice, US researchers said, detailing a partial sequencing of the dog genome.

The researchers at the Institute for Genomic Research and the Center for the Advancement of Genomics assembled 6.22 million sequences of dog DNA for nearly 80 percent coverage of the genome, they said in a statement.

"Comparing the dog sequence data with current drafts of the human and mouse genome sequences showed that the dog lineage was the first to diverge from the common ancestor of the three species, and that the human and dog are much more similar to each other at the genetic level than to the mouse," they said in results published in the review Science.

The project found that more than 25 percent, or 650 million base pairs, of DNA overlap between human and dog.

"The sequence data was used to identify an equivalent dog gene for 75 percent of known human genes," they added.

"In little more than a decade, genomics has advanced greatly and we now have approximately 150 completed genomes including the human, mouse and fruit fly, in the public domain," said Craig Venter, president of the TCAG.

"Our new method is an efficient and effective way of sequencing that will allow more organisms to be analyzed while still providing significant information."

(Agencies)

美国研究者称,他们仔细研究了狗的基因组部分序列,认为从遗传角度讲狗比老鼠更接近人类。

基因组研究所和先进基因体学研究中心的研究者们在报告中说他们搜集了622万组狗的DNA序列,囊括了接近80%的基因组。

他们在《科学》杂志上发表的结果中提到:“通过比较狗基因组序列数据和现有的人类基因组草图以及老鼠的基因组序列,结果显示狗类家族首先从三者共同的祖先中分离出来,在遗传等级上狗比老鼠更接近人类,与人类更相似。”

该研究发现人类和狗互相重合的DNA超过25%,相当于6.5亿硷基对。

他们还说:“序列数据被用来确认与75%的已知人类基因相对应的狗的基因。”

先进基因体学研究中心主任克雷格·文特尔说“在近十年里,基因体学发展迅速,我们在开放的领域里已经有大约150组完整的基因组,包括人类,老鼠和果蝇。”

“我们的新排序方法既经济又有效,能够分析更多的生物体,提供重要的信息。”

(中国日报网站译)

 
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